Research publications

Peer-reviewed published studies that are supported by TIA.
BIOMED PHARMACOTHER., SEPT 2019
J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain
Park TSW, Khan N, Kuo A, Nicholson JR, Corradini L, Smith MT
CLIN EXP PHARMACOL PHYSIOL., JULY 2019
Nitric oxide modulates μ-opioid receptor function in vitro.
Huang L, Wyse BD, Williams CM, Smith MT
HAEMATOLOGICA, MAY 2019
CD27, CD201, FLT3, CD48, And CD150 Cell Surface Staining Identifies Long-Term Mouse Hematopoietic Stem Cells In Immunodeficient Non-Obese Diabetic Severe Combined Immune Deficient Derived Strains
Nowlan B, Williams ED, Doran MR, Levesque JP
METHODS PROTOC., MAY 2019
Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy
Adiraju SKS, Shekar K, Tesar P, Naidoo R, Rapchuk I, Belz S, Fraser JF, Smith MT, Ghassabian S
J. MED. CHEM., ARPIL 2019
Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists
Deora GSQin CXVecchio EADebono AJPriebbenow DLBrady RMBeveridge JTeguh SCDeo M,    May LTKrippner GRitchie RHBaell JB
PLoS ONE, MARCH 2019
Media composition modulates human embryonic stem cell morphology and may influence preferential lineage differentiation potential
Harkness L, Chen X, Gillard M, Gray PP, Davies AM
FRONT IMMUNOL., MARCH 2019
Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury
Alexander KA, Tseng HW, Fleming W, Jose B, Salga M, Kulina I, Millard SM, Pettit AR, Genêt F, Levesque JP
RAPID COMMUNICATION, FEB 2019
Sustained-Release Hydromorphone Microparticles Produced by Supercritical Fluid Polymer Encapsulation
Han FY, Whittaker A, Howdle SM, Naylor A, Shabir-Ahmed A, Smith MT

PHARMACEUTICS, DEC 2018
Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation.
Han FY, Whittaker AK, Howdle SM, Naylor A, Shabir-Ahmed A, Zhang C, Smith MT

PHARMACEUTICAL RESEARCH, NOV 2018
Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds
Katneni K, Pham T, Saunders J, Chen G, Patil R, White KL, Abla N, Chiu FCK, Shackleford DM, Charman SA
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, OCT 2018
Whole-Exome Sequencing Implicates SCN2A in Episodic Ataxia, but Multiple Ion Channel Variants May Contribute to Phenotypic Complexity
Maksemous N, Smith RA, Sutherland HG, Sampaio H, and Griffiths LR. 

FRONT PHARMACOL., MAY 2018

The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain.
Shenoy PA, Kuo A, Khan N, Gorham L, Nicholson JR, Corradini L, Vetter I, Smith MT
CLIN EXP PHARMACOL PHYSIOL., MAY 2018
Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy.
Han FY, Kuo A, Nicholson JR, Corradinni L, Smith MT

INFLAMMOPHARMACOLOGY, MAY 2018
Chronic low back pain: a mini-review on pharmacological management an pathophysiological insights from clinical and pre-clinical data.
Park TSW, Kuo A, Smith MT

BMJ OPEN, FEB 2018

Prospective registration trends, reasons for retrospective registration and mechanisms to increase prospective registration compliance: descriptive
analysis and survey
Hunter KE, Seidler AL,Askie LM

NAT COMMUN., FEB 2018
Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury'
Qin CX, May LT, Sexton PM, DeBono AJ, Baell JB, Christopoulos A, Ritchie RH

INFLAMMOPHARMACOLOGY, FEB 2018
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain.
Khan N, Kuo A, Brockman DA, Cooper MA, Smith MT

ACS CHEM BIOL., JAN 2018
Seven year itch: Pan-assay interference compounds (PAINS) in 2017-utility and limitations.
Baell JB, Nissink JWM

J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI., JAN 2018
An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma.
Moosavi SM, Shekar K, Fraser JF, Smith MT, Ghassabian S.

SCI REP., DEC 2017
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity
Menon D, Innes A, Oakley AJ, Dahlstrom JE, Jensen LM, Brüstle A, Tummala P, Rooke M, Casarotto MG, Baell JB, Nguyen N, Xie Y, Cuellar M, Strasser J, Dahlin JL, Walters MA, Burgio G, O'Neill LAJ, Board PG

JCI INSIGHT, NOV 2017
Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications
Torossian F, Guerton B, Anginot A, Alexander KA, Desterke C, Soave S, Tseng HW, Arouche N, Boutin L, Kulina I, Salga M, Jose B, Pettit AR, Clay D, Rochet N, Vlachos E, Genet G, Debaud C, Denormandie P, Genet F, Sims NA, Banzet S, Levesque JP, Lataillade JJ, Le Bousse-Kerdilès MC

FRONT. MOL. NEUROSCI., NOV 2017
Attenuation of the infiltration of angiotensin II expressing CD3+ T-Cells and the modulation of nerve growth factor in lumbar dorsal root ganglia – A possible mechanism underpinning analgesia produced by EMA300, an angiotensin II type 2 (AT2) receptor antagonist
Khan N, Muralidharan A, Smith MT

CELL‐BASED DRUG DEVELOPMENT, SCREENING, AND TOXICOLOGY, FEB 2017
Mesenchymal stromal cell therapy for chronic lung allograft dysfunction: results of a first‐in‐man study
Chambers DC, Enever D, Lawrence S, Sturm MJ, Herrmann R, Yerkovich S, Musk M, Hopkins PM. 

J HEADACHE PAIN, DEC 2016
The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients
Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, Lea R, Smith M, Griffiths L

J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI., DEC 2016
High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC-MS/MS instrumentation
Moosavi SM, Shekar K, Fraser J, Smith MT, Ghassabian S

ACS MED CHEM LETT., JUNE 2016
In Vitro metabolic stability and in vivo diodistribution of 3-methyl-4-furoxancarbaldehyde using PET imaging in rats
Pippin AB, Mohd Arshad ZH, Voll RJ, Nye JA, Ghassabian S, Williams CM, Mancini A, Liotta DC, Smith MT, Goodman MM

AMEDIATORS OF INFLAMMATION, JUNE 2015
Gestation related gene expression of the endocannabinoid pathway in rat placenta
Vaswani, K., Chan, H., Peiris, H.N., Nitert, M.D., Bradley, R.J., Armitage, J.A., Rice, G., & Mitchell, M.D

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