Small Molecules
Available expertise
High Throughput Screening
We support a network of high throughput screening centres for small molecule drug discovery via Pipeline Accelerator. Capabilities supported include pre-screening assay development, library screening and/or hit validation post-screening.
Medicinal Chemistry
The Australian Translational Medicinal Chemistry Facility (ATMCF) provides support for early stage medicinal chemistry-led drug discovery. ATMCF also provides expertise in high-throughput screening (HTS) hit selection, fragment-based drug discovery (FBDD), structure-based drug design and SAR guided optimization.
Drug Candidate Optimisation
The Centre for Drug Candidate Optimisation (CDCO) has the expertise expertise and infrastructure in ADME lead optimisation to multidisciplinary drug discovery teams for improved compound design, selection and progression. The services provided by CDCO are in compliance with ISO 9001:2015 Quality Management System
Preclinical Efficacy Testing
The Centre for Integrated Preclinical Drug Development (CIPDD) has state-of-the-art physical infrastructure and it is a NATA GLP-recognized new drug development facility. CIPDD's core capabilities include preclinical efficacy studies in rodent models and the development of new rodent models of human diseases.
Australian Lead Identification Consortium (ALIDC) Library
TIA subsidises access to >200,000 compounds ALIDC screening library stored at Compounds Australia. Pipeline Accelerator provides additional subsidy to access ALIDC compound library.
Action plan for hit identification (APHID) Capability
TIA supports APHID, the hit triage expert group located within ATMCF, to assess the potential of hits identified following high-throughput screening campaigns.
FROM DISCOVERY TO THE CLINIC : Steering the innovation pipeline from research discovery to therapeutics
Key messages:
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It is never too early to reach out to the facilities within TIA’s Small Molecules Capability for advice on making the transition from research to development.
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Early engagement with TIA or one of the facilities will enable you to leverage their significant expertise and expedite your translation to clinical development.
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Understanding the process and the fact that you don’t have to do it all yourself will maximise the chances of success.
