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Capabilities​/ Services offered

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• National compound management and logistics facility for small molecule compound libraries and natural product extract and fraction libraries.

• Researcher access to critical infrastructure and expertise for flexible, reproducible
  and cost effect sample handling to support national screening initiatives.

• Provides storage and management of the national open access compound collection, GRIDD's NatureBank collection and numerous proprietary compound collections.

Capabilities/Services offered  >

Compounds Australia

Pipeline Accelerator

Voucher scheme to support access to TIA facilities

This round of the Pipeline Accelerator scheme seeks to support meritorious therapeutic development projects that specifically relate to drug discovery through screening of small molecule libraries against drug targets. This can also include pre-screening assay development and/or hit validation post-screening.

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Applications close on 31st Oct 2020.

Capabilities/Services offered  >

Australian Translational Medicinal Chemistry Facility 

Capabilities​/ Services offered

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• Optimisation of screening hits and lead compounds

• Mechanism- or substrate-based design and synthesis of enzyme inhibitors

• Advice on drug discovery strategy including literature/patent searching and creating intellectual property

• Custom synthesis of known/novel compounds

• Other chemistry needs eg. targeted drug delivery and novel linker design and synthesis

Capabilities/Services offered  >

Centre for Drug Candidate Optimisation

Capabilities​/ Services offered

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• Integrated in vitro studies to assess ADME

• Physicochemical profiling and characterisation

• Drug metabolism, metabolite identification, and assessment of metabolic drug interactions

• Assessment of permeability and binding properties

• Small animal pharmacokinetic studies to determine clearance mechanisms and oral bioavailability

• Discovery stage bioanalysis by LC MS/MS

Capabilities/Services offered  >

Centre for Integrated Preclinical Drug Development

Capabilities​/ Services offered

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• Preclinical efficacy studies in rodent models of human disease

• New rodent models of human disease in response to collaborator need

• Training of research students in related techniques in response to academic collaborator request

Capabilities/Services offered  >

TetraQ

Capabilities​/ Services offered

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• Pharmacokinetics and screening toxicology studies in rodents to support preclinical development 

• GLP toxicology and toxicokinetics studies in rodents to enable first-in-human clinical studies